Police have seized more than $45 million of drugs in a mammoth bust in Sydney’s west.

Strike Force Sharrock detectives raided a home at South Penrith in the early hours of July 20, arresting a 47-year-old man.

Shortly after, investigators executed a search warrant at a nearby home, finding 100 kilograms of illicit drugs.

• 85kg of methylamphetamine (ice)
• 13kg of cocaine
• 2kg of MDMA

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The drugs have an estimated street value of more than $45 million.

The man has been charged with three counts of large commercial drug supply and refused bail.

He’ll reappear at Penrith Local Court on in September.

Click PLAY below to watch the arrest