A second man has been charged with dozens of sex crimes against children as part of a major police investigation in Victoria.

A 26-year-old man is already facing 70 child sex abuse offences, relating to eight children at a Melbourne Childcare Centre.

The accusations against a second man are not related to any childcare facility and involve different alleged victims.

Lucy Zelić says there needs to be a cultural shift in childcare centres, giving workers confidence to speak out about inappropriate behaviour.

Listen to more highlights from Afternoons with Lucy Zelić below: